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Tabletter fra smerte fra kategorien medikamenter foreskrives kun av lege - de tas kun som unntak for kort tid, beneath tilsyn av lege, og bare med svært alvorlig smerte. Typiske representanter for slike medisiner er tabletter Promedol og Tramadol.Det var fileørst mot slutten av 1800-tallet at en tysk kjemiker fant ut at effekten skyldtes acetylsa
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